Scientists hope maggots can help produce an antibiotic that
can tackle strains of the MRSA superbug.
The researchers at Swansea University are
developing the antibiotic from maggot secretions from the common green bottle
fly.They hope to develop it into an injection, pill or ointment to tackle 12
strains of MRSA, as well as as well as E.coli and C.difficile.
The research also involved scientists at
universities in Belgium.
The antibiotic has been named Seraticin and scientists have studied how it can
prevent infection. It takes around 20 maggots to make one drop of the
antibiotic in its purified form.
Scientists now hope to complete the
identification of the compound and find a way to synthesise it, before it can
be tested on human cells and trialled to determine its medical effectiveness.
Using live maggots on infected wounds is a well established method of tackling
infections
'Bacterial growth'
Professor Norman Ratcliffe, a principal
researcher on the project, said: "It has been a huge team effort to get to
this level and I am delighted with our progress."However there is more to
do if we are to realise the maximum benefits from this discovery.
He said the next stage was to confirm its
exact identity using mass spectrometry and nuclear magnetic resonance analyses
to produce it chemically on a larger scale.Dr Alun Morgan of ZooBiotic Ltd,
based in Wales,
that supplied the maggots for the project, said: "Maggots are great little
multi-taskers."They produce enzymes that clean wounds, they make a wound
more alkaline which may slow bacterial growth and finally they produce a range
of antibacterial chemicals that stop the bacteria growing."
The research was funded by leading charity
Action Medical Research, with support from the Rosetrees Trust.The University
of Manchester has been carrying out similar research, after using green bottle
fly larvae to treat diabetic patients, whose foot ulcers were contaminated with
MRSA.They found that most were cured within three weeks, compared to 28 weeks
with conventional treatment.
